We are pleased to announce a new paper from Claire Elliott, Senior Toxicologist, published in Regulatory Toxicology and Pharmacology. The new paper is called “Increasing confidence in waiving dermal toxicity studies: A comparison of oral and dermal acute data with alternative approaches for agrochemicals and products“. The paper examines the refinement of acute dermal study design and the ability to waive this study.
This review of available acute oral and dermal data from agrochemical active ingredients and associated plant protection products was to understand if there are any human safety concerns from waiving the OECD 402 dermal toxicity study. Furthermore, the evaluation was also developed to understand whether there were any potential human health implications from the change in OECD 402 study design incorporating smaller group sizes, lowering of the limit dose and use of waiver criteria.
The analysis clearly demonstrated that the OECD 402 can be confidently eliminated in its entirety from testing requirements globally, which is further applying the 3R’s principles to regulatory toxicity testing.