We aim to make a positive contribution to the science that shapes regulation.
These are some of the more recent publications our team has contributed to.
2024
H. Kamp, N. Aygun Kocabas, F. Faulhammer, N. Synhaeve, E. Rushton, B. Flick, V. Giri, S. Sperber, L. G. Higgins, M. G. Penman, B. van Ravenzwaay & M. Rooseboom, 2024. Utility of in vivo metabolomics to support read-across for UVCB substances under REACH. Archives of Toxicology. View
Bennard van Ravenzwaay, Neslihan Aygun Kocabas, Frank Faulhammer, Burkhard Flick, Varun Giri, Saskia Sperber, Michael G Penman, Larry G. Higgins, Hennicke Kamp, Martijn Rooseboom, 2024. The short-term toxicity and metabolome of Dicyclopentadiene. Toxicology Letters. View
2023
Rooseboom, M., Kocabas, N.A., North, C., Radcliffe, R.J. and Segal, L., 2023. Recommendation for an occupational exposure limit for toluene. Regulatory Toxicology and Pharmacology, p.105387. View
North, C.M., Rooseboom, M., Kocabas, N.A., Synhaeve, N., Radcliffe, R.J. and Segal, L., 2023. Application of physiologically-based pharmacokinetic modeled toluene blood concentration in the assessment of short term exposure limits. Regulatory Toxicology and Pharmacology, 140, p.105380. View
Quan Shi, Juan-Carlos Carrillo, Michael G Penman, Hua Shen, Colin M North, Sophie Jia, Tilly Borsboom-Patel, Yuan Tian, Fabienne Hubert, Jason C Manton, Peter J Boogaard, 2023. Toxicological Assessment of Higher Olefins in OECD TG 422 Repeated Dose and Reproductive/Developmental Toxicity Screening Tests in Han Wistar Rats. International Journal of Toxicology. View
2022
Quan Shi, Juan-Carlos Carrillo, Michael G. Penman, Jason Manton, Elena Fioravanzo, Robert H. Powrie, Clifford R. Elcombe, Tilly Borsboom-Patel, Yuan Tian, Hua Shen, and Peter J. Boogaard, 2022. Assessment of the Intestinal Absorption of Higher Olefins by the Everted Gut Sac Model in Combination with In Silico New Approach Methodologies, Chemical Research in Toxicology, Volume 35, Issue 8, p1289-1434. View
2021
Colin M. North, A. Robert Schnatter, Martijn Rooseboom, Neslihan Aygun, Kocabas, Abigail Dalzell, Stephen D. Williams, 2021. Key event-informed risk models for benzene-induced acute myeloid leukaemia. Toxicology Letters Volume 340. View
Sophie van der Kamp, Claire Elliott, 2021. Increasing confidence in waiving dermal toxicity studies: A comparison of oral and dermal acute data with alternative approaches for agrochemicals and products. Regulatory Toxicology and Pharmacology Volume 121. View
2020
Jesamine C. Bartlett, Richard James Radcliffe, Pete Convey, Kevin A. Hughes, Scott A.L. Hayward, 2020. The effectiveness of Virkon® S disinfectant against an invasive insect and implications for Antarctic biosecurity practices. Antarctic Science, Volume 33 Issue 1. View
North, C.M., Rooseboom, M., Kocabas, N.A., Schnatter, A.R., Faulhammer, F., Williams, S.D., 2020. Modes of action considerations in threshold expectations for health effects of benzene. Toxicology Letters 334, 78–86. View
Schnatter, A.R., Rooseboom, M., Kocabas, N.A., North, C.M., Dalzell, A., Twisk, J., Faulhammer, F., Rushton, E., Boogaard, P.J., Ostapenkaite, V., Williams, S.D., 2020. Derivation of an occupational exposure limit for benzene using epidemiological study quality assessment tools. Toxicology Letters. View
William Masinja, Claire Elliott, Sandeep Modi, Steven J. Enoch, Mark T.D. Cronin, Elizabeth F. McInnes, Richard A.Currie, 2020. Comparison of the predictive nature of the genomic allergen rapid detection (GARD) assay with mammalian assays in determining the skin sensitisation potential of agrochemical active ingredients. View
An R. Van Rompay, Els Adriaens, Sandra Verstraelen, 2020. Laser Light-Based Opacitometer ‘Peira LLBO 180’: A new and validated opacitometer for use in the Bovine Corneal Opacity and Permeability (BCOP) eye irritation test method View
E.Adriaens, S.Verstraelen, B.Desprez, N.Alépée, T.Abo, D.Bagley, J.Hibatallah, K.R.Mewes, U.Pfannenbecker, A.R. Van Rompay, 2020. Overall performance of Bovine Corneal Opacity and Permeability (BCOP) Laser Light-Based Opacitometer (LLBO) test method with regard to solid and liquid chemicals testing View
2019
Segal, L., Garcia, S., Canut, L.,Diaram, S., David, R., Xu, J., and Penman, M., 2019. Evaluation of repeated dose and reproductive / developmental toxicity of 1,2-Cyclohexanedicarboxylic Acid, 1-butyl 2 (phenylmethyl) ester (P1400) in the rat. The Toxicologist, Supplement to Toxicological Sciences, 168 (1), Abstract #1540. View
2018
Delannois, F., Planty, C., Giordano, G., Destexhe, E., Stanislaus, D., Da Silva, F.T., Stegmann, J.U., Thacker, K., Reynaud, L., Garçon, N. and Segal, L., 2018. Signal management in pharmacovigilance and human risk assessment of CpG 7909, integrating embryo-fetal and post-natal developmental toxicity studies in rats and rabbits. Reproductive Toxicology, 75, pp.110-120. View
Segal, L., Penman, M. and Piriou, Y. 2018. Evaluation of the systemic toxicity and mutagenicity of OLIGOPIN®, procyanidolic oligomers (OPC) extracted from French Maritime Pine Bark Extract. Toxicology Reports 5: 531–541. View
D.R.Boverhof, J.A.Hotchkiss, M.J.LeBaron, L.M.Segal, C.Howick, 2018. Investigation of the potential non-genotoxic mode of action for 1,2-Dichloroethane (DCE)-induced mammary tumors in female rats. Toxicology Letters, Volume 295, Supplement 1, Pages S150-S151, P11-06 View
2017
Segal, L., Canut, L., Myers, D., García, S., Blee, M., Butala, J. and Penman, M., 2017. Extended OECD 422 screening study for the evaluation of substances with suspected reproductive toxicity and/or endocrine activity. Toxicology Letters, 280, p.S163. View
Segal, L., Thacker, K., Fochesato, M., Giordano, G., Garçon, N. and Destexhe, E., 2017. Intramuscularly administered herpes zoster subunit vaccine has no effects on fertility, pre-and post-natal development in Sprague-Dawley rats. Reproductive Toxicology, 69, pp.297-307. View
2016
Penman, M., Riley, A.,Candido, A.,Wood, E., Myers, D. and Segal, L. 2016. Strategies to address REACH Annex X requirements for developmental toxicity testing in a second mammalian species. Society of Toxicology Annual Meeting 2016, Late‐Breaking Abstracts Poster abstract ID: 3614 Poster Board: P306
2015
Penman, M., Banton, M., Erler, S., Moore, N. and Semmler, K., 2015. Olefins and chemical regulation in Europe: REACH. Chemico-biological interactions, 241, pp.59-65.View
Penman, M. and Piper, M. 2015. A mechanistic approach to read-across & minimising animal testing. Speciality Chemicals Magazine, pp. 46-47.
Suzanne Spaan, Rianda Gerritsen‐Ebben, Kyriaki Machera, Agathi Charistou, Niki Arapaki, Dimitra Nikolopoulou Angelos Tsakirakis Abigail Dalzell, Carmel Ramwell, Philip Bone, Chris Sinclair. Data collection on exposure assessment scenarios for operators exposed to pesticides. 24 July 2015 External scientific report - EFSAView
Abigail M. Dalzell, Pratibha Mistry, Jayne Wright, Faith. M. Williams, Colin. D.A. Brown, Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines, Toxicology Letters, Volume 235, Issue 3, 2015, Pages 189-198 View
2013
Bergkamp, L. and Penman, M. 2013.Introduction. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
Bergkamp, L. and Penman, M. 2013. Conclusion. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
Grosso, A., Crane, M. and Penman, M. 2013. REACH and strategic decision making. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
Hansen, B. and Penman, M. 2013. Is REACH achieving its objectives?. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
Penman, M. and Richards, M. 2013. REACH Consortia. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
Money, C.D., Tomenson, J.A., Penman, M.G., Boogaard, P.J. and Lewis, R.J., 2013. A systematic approach for evaluating and scoring human data. Regulatory Toxicology and Pharmacology, 66(2), pp.241-247. View>
2012
Jenkinson SE1, Chung GW, van Loon E, Bakar NS, Dalzell AM, Brown CD. The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule.Pflugers Arch. 2012 DecView
2007
Money, C.D., Jacobi, S., Penman, M.G., Rodriguez, C., De Rooij, C. and Veenstra, G., 2007. The ECETOC approach to targeted risk assessment; lessons and experiences relevant to REACH. Journal of Exposure Science and Environmental Epidemiology, 17(S1), p.S67. View
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