We aim to make a positive contribution to the science that shapes regulation.

These are some of the publications our team has contributed to.

  • 2019
    • Segal, L., Garcia, S., Canut, L.,Diaram, S., David, R., Xu, J., and Penman, M., 2019. Evaluation of repeated dose and reproductive / developmental toxicity of 1,2-Cyclohexanedicarboxylic Acid, 1-butyl 2 (phenylmethyl) ester (P1400) in the rat. The Toxicologist, Supplement to Toxicological Sciences, 168 (1), Abstract #1540. View
  • 2018
    • Delannois, F., Planty, C., Giordano, G., Destexhe, E., Stanislaus, D., Da Silva, F.T., Stegmann, J.U., Thacker, K., Reynaud, L., Garçon, N. and Segal, L., 2018. Signal management in pharmacovigilance and human risk assessment of CpG 7909, integrating embryo-fetal and post-natal developmental toxicity studies in rats and rabbits. Reproductive Toxicology, 75, pp.110-120. View
    • Segal, L., Penman, M. and Piriou, Y. 2018. Evaluation of the systemic toxicity and mutagenicity of OLIGOPIN®, procyanidolic oligomers (OPC) extracted from French Maritime Pine Bark Extract. Toxicology Reports 5: 531–541. View
    • D.R.Boverhof, J.A.Hotchkiss, M.J.LeBaron, L.M.Segal, C.Howick, 2018. Investigation of the potential non-genotoxic mode of action for 1,2-Dichloroethane (DCE)-induced mammary tumors in female rats. Toxicology Letters, Volume 295, Supplement 1, Pages S150-S151, P11-06 View
    • Tatsi, K., Shaw, B.J., Hutchinson, T.H. and Handy, R.D., 2018. Copper accumulation and toxicity in earthworms exposed to CuO nanomaterials: Effects of particle coating and soil ageing. Ecotoxicology and Environmental Safety, 166, pp.462-473. View
  • 2017
    • Lantto, T.A., Hofer, T., Myhre, O., Andersen, S., Lapenna, S., Muller, G., Kloslova, Z., Alasuvanto, T., Gissi, A., Karamertzanis, P., Martin Aparicio, A., Netzeva, T., Sobanski, T., Caley, J., Lepper, P., Verbruggen, E. and Peltola-Thies, J.R. 2017. Use of mammalian toxicokinetic data in bioaccumulation assessment. Abstract book SETAC EUROPE 27th Annual Meeting 7-11 May 2017, Brussels, Belgium. Platform presentation. View
    • Segal, L., Canut, L., Myers, D., García, S., Blee, M., Butala, J. and Penman, M., 2017. Extended OECD 422 screening study for the evaluation of substances with suspected reproductive toxicity and/or endocrine activity. Toxicology Letters, 280, p.S163. View
    • Segal, L., Thacker, K., Fochesato, M., Giordano, G., Garçon, N. and Destexhe, E., 2017. Intramuscularly administered herpes zoster subunit vaccine has no effects on fertility, pre-and post-natal development in Sprague-Dawley rats. Reproductive Toxicology, 69, pp.297-307. View
    • Tatsi, K., Hutchinson T. H. and Handy, R. D. 2017. Toxicity of Fresh and Aged Coated Cadmium Telluride Quantum Dots to the Earthworm Eisenia fetida. Poster presented at: 12th International Conference on the Environmental Effects of Nanoparticles and Nanomaterials (Birmingham, UK).
  • 2016
    • Lantto, T.A., Laakso, I., Dorman, H.J., Mauriala, T., Hiltunen, R., Kõks, S. and Raasmaja, A., 2016. Cellular stress and p53-associated apoptosis by Juniperus communis L. berry extract treatment in the human SH-SY5Y neuroblastoma cells. International journal of molecular sciences, 17(7), p.1113. View
    • Penman, M., Riley, A.,Candido, A.,Wood, E., Myers, D. and Segal, L. 2016. Strategies to address REACH Annex X requirements for developmental toxicity testing in a second mammalian species. Society of Toxicology Annual Meeting 2016, Late‐Breaking Abstracts Poster abstract ID: 3614 Poster Board: P306
    • Peltola-Thies, J., Lantto, T.A., Lapenna, S., Muller, G., Kloslova, Z., Caley, J., Andersen, S., Gudbrandsen, M., Hofer, T., Myhre, O. and Verbruggen, E., 2016. Use of toxicokinetic data in bioaccumulation assessment. Toxicology Letters, (258), p.S226. View
  • 2015
    • Penman, M., Banton, M., Erler, S., Moore, N. and Semmler, K., 2015. Olefins and chemical regulation in Europe: REACH. Chemico-biological interactions, 241, pp.59-65.View
    • Penman, M. and Piper, M. 2015. A mechanistic approach to read-across & minimising animal testing. Speciality Chemicals Magazine, pp. 46-47.
    • Tatsi, K., Turner, A., Handy, R.D. and Shaw, B.J., 2015. The acute toxicity of thallium to freshwater organisms: Implications for risk assessment. Science of the Total Environment, 536, pp.382-390. View
  • 2014
    • Tatsi, K. and Turner, A., 2014. Distributions and concentrations of thallium in surface waters of a region impacted by historical metal mining (Cornwall, UK). Science of the Total Environment, 473, pp.139-146. View
  • 2013
    • Bergkamp, L. and Penman, M. 2013.Introduction. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
    • Bergkamp, L. and Penman, M. 2013. Conclusion. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
    • Grosso, A., Crane, M. and Penman, M. 2013. REACH and strategic decision making. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
    • Hansen, B. and Penman, M. 2013. Is REACH achieving its objectives?. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
    • Penman, M. and Richards, M. 2013. REACH Consortia. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
    • Money, C.D., Tomenson, J.A., Penman, M.G., Boogaard, P.J. and Lewis, R.J., 2013. A systematic approach for evaluating and scoring human data. Regulatory Toxicology and Pharmacology, 66(2), pp.241-247. View
  • 2012
    • Ossola, B., Lantto, T.A., Puttonen, K.A., Tuominen, R.K., Raasmaja, A. and Männistö, P.T., 2012. Minocycline protects SH‐SY5Y cells from 6‐hydroxydopamine by inhibiting both caspase‐dependent and‐independent programmed cell death. Journal of neuroscience research, 90(3), pp.682-690. View
  • 2011
    • Dorman, H.D., Lantto, T.A., Raasmaja, A. and Hiltunen, R., 2011. Antioxidant, pro-oxidant and cytotoxic properties of parsley. Food & function, 2(6), pp.328-337. View
  • 2009
    • Lantto, T.A., Colucci, M., Závadová, V., Hiltunen, R. and Raasmaja, A., 2009. Cytotoxicity of curcumin, resveratrol and plant extracts from basil, juniper, laurel and parsley in SH-SY5Y and CV1-P cells. Food chemistry, 117(3), pp.405-411. View
    • Lantto, T.A., Dorman, H.D., Shikov, A.N., Pozharitskaya, O.N., Makarov, V.G., Tikhonov, V.P., Hiltunen, R. and Raasmaja, A., 2009. Chemical composition, antioxidative activity and cell viability effects of a Siberian pine (Pinus sibirica Du Tour) extract. Food Chemistry, 112(4), pp.936-943. View
  • 2007
    • Jack, E., Hakvoort, H.W., Reumer, A., Verkleij, J.A., Schat, H. and Ernst, W.H., 2007. Real-time PCR analysis of metallothionein-2b expression in metallicolous and non-metallicolous populations of Silene vulgaris (Moench) Garcke. Environmental and Experimental Botany, 59,(1), pp.84-91. View
    • Money, C.D., Jacobi, S., Penman, M.G., Rodriguez, C., De Rooij, C. and Veenstra, G., 2007. The ECETOC approach to targeted risk assessment; lessons and experiences relevant to REACH. Journal of Exposure Science and Environmental Epidemiology, 17(S1), p.S67. View
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