Publications
We make a positive contribution to the science that shapes regulation.
2025
- Keith Morris-Schaffer, Larry Higgins, Neslihan Aygun Kocabas, Frank Faulhammer, Alexandra Cordova, Elaine Freeman, Hennicke Kamp, Muna Nahar, Emily Richmond, Martijn Rooseboom, 2025. A weight of evidence review on the mode of action, adversity, and the human relevance of xylene’s observed thyroid effects in rats. Critical Reviews in Toxicology, 1–26. View
- Frank Faulhammer, Martijn Rooseboom, Neslihan Aygun Kocabas, Josje H. E. Arts, Alexandra Cordova, Elaine Freeman, Larry G. Higgins, Muna Nahar, Emily Richmond, Steffen Schneider & Keith Morris-Schaffer, 2025. Xylene: weight of evidence approach case study to determine the need for an extended one generation reproductive study with a developmental neurotoxicity animal cohort. Critical Reviews in Toxicology, 54(10), 925–952. View
- Quan S, Michael G. Penman, Juan-Carlos Carrillo, Jamie Dunn, Hua Shen, Sophie Jia, An R. Van Rompay, Fabienne Hubert, Peter J. Boogaard, 2025. Prenatal developmental toxicity evaluation of higher olefins in Sprague-Dawley rats. Reproductive Toxicology, Volume 132. View
2024
- F Faulhammer, B van Ravenzwaay, AR Schnatter, M Rooseboom, H Kamp, B Flick, V Giri, S Sperber, LG Higgins, MG Penman, N Kocabas, The short-term toxicity and metabolome of Benzene. Toxicology Letters. View
- H. Kamp, N. Aygun Kocabas, F. Faulhammer, N. Synhaeve, E. Rushton, B. Flick, V. Giri, S. Sperber, L. G. Higgins, M. G. Penman, B. van Ravenzwaay & M. Rooseboom, 2024. Utility of in vivo metabolomics to support read-across for UVCB substances under REACH. Archives of Toxicology. View
- Bennard van Ravenzwaay, Neslihan Aygun Kocabas, Frank Faulhammer, Burkhard Flick, Varun Giri, Saskia Sperber, Michael G Penman, Larry G. Higgins, Hennicke Kamp, Martijn Rooseboom, 2024. The short-term toxicity and metabolome of Dicyclopentadiene. Toxicology Letters. View
2023
- Rooseboom, M., Kocabas, N.A., North, C., Radcliffe, R.J. and Segal, L., 2023. Recommendation for an occupational exposure limit for toluene. Regulatory Toxicology and Pharmacology, p.105387. View
- North, C.M., Rooseboom, M., Kocabas, N.A., Synhaeve, N., Radcliffe, R.J. and Segal, L., 2023. Application of physiologically-based pharmacokinetic modeled toluene blood concentration in the assessment of short term exposure limits. Regulatory Toxicology and Pharmacology, 140, p.105380. View
- Quan Shi, Juan-Carlos Carrillo, Michael G Penman, Hua Shen, Colin M North, Sophie Jia, Tilly Borsboom-Patel, Yuan Tian, Fabienne Hubert, Jason C Manton, Peter J Boogaard, 2023. Toxicological Assessment of Higher Olefins in OECD TG 422 Repeated Dose and Reproductive/Developmental Toxicity Screening Tests in Han Wistar Rats. International Journal of Toxicology. View
2022
- Quan Shi, Juan-Carlos Carrillo, Michael G. Penman, Jason Manton, Elena Fioravanzo, Robert H. Powrie, Clifford R. Elcombe, Tilly Borsboom-Patel, Yuan Tian, Hua Shen, and Peter J. Boogaard, 2022. Assessment of the Intestinal Absorption of Higher Olefins by the Everted Gut Sac Model in Combination with In Silico New Approach Methodologies, Chemical Research in Toxicology, Volume 35, Issue 8, p1289-1434. View
2021
- Colin M. North, A. Robert Schnatter, Martijn Rooseboom, Neslihan Aygun, Kocabas, Abigail Dalzell, Stephen D. Williams, 2021. Key event-informed risk models for benzene-induced acute myeloid leukaemia. Toxicology Letters Volume 340. View
- Sophie van der Kamp, Claire Elliott, 2021. Increasing confidence in waiving dermal toxicity studies: A comparison of oral and dermal acute data with alternative approaches for agrochemicals and products. Regulatory Toxicology and Pharmacology Volume 121. View
2020
- Jesamine C. Bartlett, Richard James Radcliffe, Pete Convey, Kevin A. Hughes, Scott A.L. Hayward, 2020. The effectiveness of Virkon® S disinfectant against an invasive insect and implications for Antarctic biosecurity practices. Antarctic Science, Volume 33 Issue 1. View
- North, C.M., Rooseboom, M., Kocabas, N.A., Schnatter, A.R., Faulhammer, F., Williams, S.D., 2020. Modes of action considerations in threshold expectations for health effects of benzene. Toxicology Letters 334, 78–86. View
- Schnatter, A.R., Rooseboom, M., Kocabas, N.A., North, C.M., Dalzell, A., Twisk, J., Faulhammer, F., Rushton, E., Boogaard, P.J., Ostapenkaite, V., Williams, S.D., 2020. Derivation of an occupational exposure limit for benzene using epidemiological study quality assessment tools. Toxicology Letters. View
- William Masinja, Claire Elliott, Sandeep Modi, Steven J. Enoch, Mark T.D. Cronin, Elizabeth F. McInnes, Richard A.Currie, 2020. Comparison of the predictive nature of the genomic allergen rapid detection (GARD) assay with mammalian assays in determining the skin sensitisation potential of agrochemical active ingredients. View
2019
- Segal, L., Garcia, S., Canut, L.,Diaram, S., David, R., Xu, J., and Penman, M., 2019. Evaluation of repeated dose and reproductive / developmental toxicity of 1,2-Cyclohexanedicarboxylic Acid, 1-butyl 2 (phenylmethyl) ester (P1400) in the rat. The Toxicologist, Supplement to Toxicological Sciences, 168 (1), Abstract #1540. View
2018
- Delannois, F., Planty, C., Giordano, G., Destexhe, E., Stanislaus, D., Da Silva, F.T., Stegmann, J.U., Thacker, K., Reynaud, L., Garçon, N. and Segal, L., 2018. Signal management in pharmacovigilance and human risk assessment of CpG 7909, integrating embryo-fetal and post-natal developmental toxicity studies in rats and rabbits. Reproductive Toxicology, 75, pp.110-120. View
- Segal, L., Penman, M. and Piriou, Y. 2018. Evaluation of the systemic toxicity and mutagenicity of OLIGOPIN®, procyanidolic oligomers (OPC) extracted from French Maritime Pine Bark Extract. Toxicology Reports 5: 531–541. View
- D.R.Boverhof, J.A.Hotchkiss, M.J.LeBaron, L.M.Segal, C.Howick, 2018. Investigation of the potential non-genotoxic mode of action for 1,2-Dichloroethane (DCE)-induced mammary tumors in female rats. Toxicology Letters, Volume 295, Supplement 1, Pages S150-S151, P11-06 View
2017
- Segal, L., Canut, L., Myers, D., García, S., Blee, M., Butala, J. and Penman, M., 2017. Extended OECD 422 screening study for the evaluation of substances with suspected reproductive toxicity and/or endocrine activity. Toxicology Letters, 280, p.S163. View
- Segal, L., Thacker, K., Fochesato, M., Giordano, G., Garçon, N. and Destexhe, E., 2017. Intramuscularly administered herpes zoster subunit vaccine has no effects on fertility, pre-and post-natal development in Sprague-Dawley rats. Reproductive Toxicology, 69, pp.297-307. View
2016
- Penman, M., Riley, A.,Candido, A.,Wood, E., Myers, D. and Segal, L. 2016. Strategies to address REACH Annex X requirements for developmental toxicity testing in a second mammalian species. Society of Toxicology Annual Meeting 2016, Late‐Breaking Abstracts Poster abstract ID: 3614 Poster Board: P306
2015
- Penman, M., Banton, M., Erler, S., Moore, N. and Semmler, K., 2015. Olefins and chemical regulation in Europe: REACH. Chemico-biological interactions, 241, pp.59-65.View
- Penman, M. and Piper, M. 2015. A mechanistic approach to read-across & minimising animal testing. Speciality Chemicals Magazine, pp. 46-47.
2013
- Bergkamp, L. and Penman, M. 2013.Introduction. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
- Bergkamp, L. and Penman, M. 2013. Conclusion. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
- Grosso, A., Crane, M. and Penman, M. 2013. REACH and strategic decision making. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
- Hansen, B. and Penman, M. 2013. Is REACH achieving its objectives?. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
- Penman, M. and Richards, M. 2013. REACH Consortia. In: Bergkamp, L. ed., 2013. The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
- Money, C.D., Tomenson, J.A., Penman, M.G., Boogaard, P.J. and Lewis, R.J., 2013. A systematic approach for evaluating and scoring human data. Regulatory Toxicology and Pharmacology, 66(2), pp.241-247. View
2007
- Money, C.D., Jacobi, S., Penman, M.G., Rodriguez, C., De Rooij, C. and Veenstra, G., 2007. The ECETOC approach to targeted risk assessment; lessons and experiences relevant to REACH. Journal of Exposure Science and Environmental Epidemiology, 17(S1), p.S67. View
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