Our peer-reviewed publications reflect Penman Consulting’s contribution to regulatory science and policy development, supporting evidence-based decision making across chemical and product regulation.
Scientific Publications
Peer-reviewed research and regulatory science underpinning our advisory work
2026
Toxicokinetic and Partial Mass Balance Assessment of 14C-Alpha Olefins in Rats
Quan Shi 1,* , Jamie Dunn 2, Juan-Carlos Carrillo 1, Michael G. Penman 2, Robert H. Powrie 3, Corinne Haines 2,3 ,Hua Shen 4, Yuan Tian 5, Sophie Jia 6, Fabienne Hubert 7 and Peter J. Boogaard 8
2025
Prenatal developmental toxicity evaluation of higher olefins in Sprague-Dawley rats. Reproductive Toxicology, Volume 132.
Quan S, Michael G. Penman, Juan-Carlos Carrillo, Jamie Dunn, Hua Shen, Sophie Jia, An R. Van Rompay, Fabienne Hubert, Peter J. Boogaard, 2025.
2025
Xylene: weight of evidence approach case study to determine the need for an extended one generation reproductive study with a developmental neurotoxicity animal cohort. Critical Reviews in Toxicology, 54(10), 925–952.
Frank Faulhammer, Martijn Rooseboom, Neslihan Aygun Kocabas, Josje H. E. Arts, Alexandra Cordova, Elaine Freeman, Larry G. Higgins, Muna Nahar, Emily Richmond, Steffen Schneider & Keith Morris-Schaffer, 2025.
2023
Toxicological Assessment of Higher Olefins in OECD TG 422 Repeated Dose and Reproductive/Developmental Toxicity Screening Tests in Han Wistar Rats. International Journal of Toxicology.
Quan Shi, Juan-Carlos Carrillo, Michael G Penman, Hua Shen, Colin M North, Sophie Jia, Tilly Borsboom-Patel, Yuan Tian, Fabienne Hubert, Jason C Manton, Peter J Boogaard, 2023.
2022
Assessment of the Intestinal Absorption of Higher Olefins by the Everted Gut Sac Model in Combination with In Silico New Approach Methodologies, Chemical Research in Toxicology, Volume 35, Issue 8, p1289-1434.
Quan Shi, Juan-Carlos Carrillo, Michael G. Penman, Jason Manton, Elena Fioravanzo, Robert H. Powrie, Clifford R. Elcombe, Tilly Borsboom-Patel, Yuan Tian, Hua Shen, and Peter J. Boogaard, 2022.
2020
Evaluation of repeated dose and reproductive / developmental toxicity of 1,2-Cyclohexanedicarboxylic Acid, 1-butyl 2 (phenylmethyl) ester (P1400) in the rat. The Toxicologist, Supplement to Toxicological Sciences, 168 (1), Abstract #1540.
Segal, L., Garcia, S., Canut, L.,Diaram, S., David, R., Xu, J., and Penman, M., 2019.
2018
Evaluation of the systemic toxicity and mutagenicity of OLIGOPIN®, procyanidolic oligomers (OPC) extracted from French Maritime Pine Bark Extract. Toxicology Reports 5: 531–541.
Segal, L., Penman, M. and Piriou, Y. 2018.
2018
Signal management in pharmacovigilance and human risk assessment of CpG 7909, integrating embryo-fetal and post-natal developmental toxicity studies in rats and rabbits. Reproductive Toxicology, 75, pp.110-120.
Delannois, F., Planty, C., Giordano, G., Destexhe, E., Stanislaus, D., Da Silva, F.T., Stegmann, J.U., Thacker, K., Reynaud, L., Garçon, N. and Segal, L., 2018.
2017
Intramuscularly administered herpes zoster subunit vaccine has no effects on fertility, pre-and post-natal development in Sprague-Dawley rats. Reproductive Toxicology, 69, pp.297-307.
Segal, L., Thacker, K., Fochesato, M., Giordano, G., Garçon, N. and Destexhe, E., 2017.
2016
Strategies to address REACH Annex X requirements for developmental toxicity testing in a second mammalian species. Society of Toxicology Annual Meeting 2016, Late‐Breaking Abstracts Poster abstract ID: 3614 Poster Board: P306
Penman, M., Riley, A.,Candido, A.,Wood, E., Myers, D. and Segal, L. 2016.
2013
A systematic approach for evaluating and scoring human data. Regulatory Toxicology and Pharmacology, 66(2), pp.241-247.
Money, C.D., Tomenson, J.A., Penman, M.G., Boogaard, P.J. and Lewis, R.J., 2013.