Our peer-reviewed publications reflect Penman Consulting’s contribution to regulatory science and policy development, supporting evidence-based decision making across chemical and product regulation.
Scientific Publications
Peer-reviewed research and regulatory science underpinning our advisory work
2026
Toxicokinetic and Partial Mass Balance Assessment of 14C-Alpha Olefins in Rats
Quan Shi 1,* , Jamie Dunn 2, Juan-Carlos Carrillo 1, Michael G. Penman 2, Robert H. Powrie 3, Corinne Haines 2,3 ,Hua Shen 4, Yuan Tian 5, Sophie Jia 6, Fabienne Hubert 7 and Peter J. Boogaard 8
2025
Prenatal developmental toxicity evaluation of higher olefins in Sprague-Dawley rats. Reproductive Toxicology, Volume 132.
Quan S, Michael G. Penman, Juan-Carlos Carrillo, Jamie Dunn, Hua Shen, Sophie Jia, An R. Van Rompay, Fabienne Hubert, Peter J. Boogaard, 2025.
2024
The short-term toxicity and metabolome of Benzene. Toxicology Letters.
F Faulhammer, B van Ravenzwaay, AR Schnatter, M Rooseboom, H Kamp, B Flick, V Giri, S Sperber, LG Higgins, MG Penman, N Kocabas.
2024
The short-term toxicity and metabolome of Dicyclopentadiene. Toxicology Letters.
Bennard van Ravenzwaay, Neslihan Aygun Kocabas, Frank Faulhammer, Burkhard Flick, Varun Giri, Saskia Sperber, Michael G Penman, Larry G. Higgins, Hennicke Kamp, Martijn Rooseboom, 2024.
2023
Toxicological Assessment of Higher Olefins in OECD TG 422 Repeated Dose and Reproductive/Developmental Toxicity Screening Tests in Han Wistar Rats. International Journal of Toxicology.
Quan Shi, Juan-Carlos Carrillo, Michael G Penman, Hua Shen, Colin M North, Sophie Jia, Tilly Borsboom-Patel, Yuan Tian, Fabienne Hubert, Jason C Manton, Peter J Boogaard, 2023.
2022
Assessment of the Intestinal Absorption of Higher Olefins by the Everted Gut Sac Model in Combination with In Silico New Approach Methodologies, Chemical Research in Toxicology, Volume 35, Issue 8, p1289-1434.
Quan Shi, Juan-Carlos Carrillo, Michael G. Penman, Jason Manton, Elena Fioravanzo, Robert H. Powrie, Clifford R. Elcombe, Tilly Borsboom-Patel, Yuan Tian, Hua Shen, and Peter J. Boogaard, 2022.
2020
Modes of action considerations in threshold expectations for health effects of benzene. Toxicology Letters 334, 78–86.
North, C.M., Rooseboom, M., Kocabas, N.A., Schnatter, A.R., Faulhammer, F., Williams, S.D., 2020.
2018
Investigation of the potential non-genotoxic mode of action for 1,2-Dichloroethane (DCE)-induced mammary tumors in female rats. Toxicology Letters, Volume 295, Supplement 1, Pages S150-S151, P11-06
D.R.Boverhof, J.A.Hotchkiss, M.J.LeBaron, L.M.Segal, C.Howick, 2018.
2018
Signal management in pharmacovigilance and human risk assessment of CpG 7909, integrating embryo-fetal and post-natal developmental toxicity studies in rats and rabbits. Reproductive Toxicology, 75, pp.110-120.
Delannois, F., Planty, C., Giordano, G., Destexhe, E., Stanislaus, D., Da Silva, F.T., Stegmann, J.U., Thacker, K., Reynaud, L., Garçon, N. and Segal, L., 2018.
2015
A mechanistic approach to read-across & minimising animal testing. Speciality Chemicals Magazine, pp. 46-47.
Penman, M. and Piper, M. 2015.