Our peer-reviewed publications reflect Penman Consulting’s contribution to regulatory science and policy development, supporting evidence-based decision making across chemical and product regulation.
Scientific Publications
Peer-reviewed research and regulatory science underpinning our advisory work
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All Publications 33
2026
Toxicokinetic and Partial Mass Balance Assessment of 14C-Alpha Olefins in Rats
Quan Shi 1,* , Jamie Dunn 2, Juan-Carlos Carrillo 1, Michael G. Penman 2, Robert H. Powrie 3, Corinne Haines 2,3 ,Hua Shen 4, Yuan Tian 5, Sophie Jia 6, Fabienne Hubert 7 and Peter J. Boogaard 8
2025
A weight of evidence review on the mode of action, adversity, and the human relevance of xylene’s observed thyroid effects in rats. Critical Reviews in Toxicology, 1–26.
Keith Morris-Schaffer, Larry Higgins, Neslihan Aygun Kocabas, Frank Faulhammer, Alexandra Cordova, Elaine Freeman, Hennicke Kamp, Muna Nahar, Emily Richmond, Martijn Rooseboom, 2025.
2025
Prenatal developmental toxicity evaluation of higher olefins in Sprague-Dawley rats. Reproductive Toxicology, Volume 132.
Quan S, Michael G. Penman, Juan-Carlos Carrillo, Jamie Dunn, Hua Shen, Sophie Jia, An R. Van Rompay, Fabienne Hubert, Peter J. Boogaard, 2025.
2025
Xylene: weight of evidence approach case study to determine the need for an extended one generation reproductive study with a developmental neurotoxicity animal cohort. Critical Reviews in Toxicology, 54(10), 925–952.
Frank Faulhammer, Martijn Rooseboom, Neslihan Aygun Kocabas, Josje H. E. Arts, Alexandra Cordova, Elaine Freeman, Larry G. Higgins, Muna Nahar, Emily Richmond, Steffen Schneider & Keith Morris-Schaffer, 2025.
2024
The short-term toxicity and metabolome of Benzene. Toxicology Letters.
F Faulhammer, B van Ravenzwaay, AR Schnatter, M Rooseboom, H Kamp, B Flick, V Giri, S Sperber, LG Higgins, MG Penman, N Kocabas.
2024
The short-term toxicity and metabolome of Dicyclopentadiene. Toxicology Letters.
Bennard van Ravenzwaay, Neslihan Aygun Kocabas, Frank Faulhammer, Burkhard Flick, Varun Giri, Saskia Sperber, Michael G Penman, Larry G. Higgins, Hennicke Kamp, Martijn Rooseboom, 2024.
2024
Utility of in vivo metabolomics to support read-across for UVCB substances under REACH. Archives of Toxicology.
H. Kamp, N. Aygun Kocabas, F. Faulhammer, N. Synhaeve, E. Rushton, B. Flick, V. Giri, S. Sperber, L. G. Higgins, M. G. Penman, B. van Ravenzwaay & M. Rooseboom, 2024.
2023
Application of physiologically-based pharmacokinetic modeled toluene blood concentration in the assessment of short term exposure limits. Regulatory Toxicology and Pharmacology, 140, p.105380.
North, C.M., Rooseboom, M., Kocabas, N.A., Synhaeve, N., Radcliffe, R.J. and Segal, L., 2023.
2023
Recommendation for an occupational exposure limit for toluene. Regulatory Toxicology and Pharmacology, p.105387. View
Rooseboom, M., Kocabas, N.A., North, C., Radcliffe, R.J. and Segal, L., 2023.
2023
Toxicological Assessment of Higher Olefins in OECD TG 422 Repeated Dose and Reproductive/Developmental Toxicity Screening Tests in Han Wistar Rats. International Journal of Toxicology.
Quan Shi, Juan-Carlos Carrillo, Michael G Penman, Hua Shen, Colin M North, Sophie Jia, Tilly Borsboom-Patel, Yuan Tian, Fabienne Hubert, Jason C Manton, Peter J Boogaard, 2023.
2022
Assessment of the Intestinal Absorption of Higher Olefins by the Everted Gut Sac Model in Combination with In Silico New Approach Methodologies, Chemical Research in Toxicology, Volume 35, Issue 8, p1289-1434.
Quan Shi, Juan-Carlos Carrillo, Michael G. Penman, Jason Manton, Elena Fioravanzo, Robert H. Powrie, Clifford R. Elcombe, Tilly Borsboom-Patel, Yuan Tian, Hua Shen, and Peter J. Boogaard, 2022.
2021
Increasing confidence in waiving dermal toxicity studies: A comparison of oral and dermal acute data with alternative approaches for agrochemicals and products. Regulatory Toxicology and Pharmacology Volume 121.
Sophie van der Kamp, Claire Elliott, 2021.
2021
Key event-informed risk models for benzene-induced acute myeloid leukaemia. Toxicology Letters Volume 340.
Colin M. North, A. Robert Schnatter, Martijn Rooseboom, Neslihan Aygun, Kocabas, Abigail Dalzell, Stephen D. Williams, 2021.
2020
Comparison of the predictive nature of the genomic allergen rapid detection (GARD) assay with mammalian assays in determining the skin sensitisation potential of agrochemical active ingredients.
William Masinja, Claire Elliott, Sandeep Modi, Steven J. Enoch, Mark T.D. Cronin, Elizabeth F. McInnes, Richard A.Currie, 2020.
2020
Derivation of an occupational exposure limit for benzene using epidemiological study quality assessment tools. Toxicology Letters.
Schnatter, A.R., Rooseboom, M., Kocabas, N.A., North, C.M., Dalzell, A., Twisk, J., Faulhammer, F., Rushton, E., Boogaard, P.J., Ostapenkaite, V., Williams, S.D., 2020.
2020
Evaluation of repeated dose and reproductive / developmental toxicity of 1,2-Cyclohexanedicarboxylic Acid, 1-butyl 2 (phenylmethyl) ester (P1400) in the rat. The Toxicologist, Supplement to Toxicological Sciences, 168 (1), Abstract #1540.
Segal, L., Garcia, S., Canut, L.,Diaram, S., David, R., Xu, J., and Penman, M., 2019.
2020
Modes of action considerations in threshold expectations for health effects of benzene. Toxicology Letters 334, 78–86.
North, C.M., Rooseboom, M., Kocabas, N.A., Schnatter, A.R., Faulhammer, F., Williams, S.D., 2020.
2020
The effectiveness of Virkon® S disinfectant against an invasive insect and implications for Antarctic biosecurity practices. Antarctic Science, Volume 33 Issue 1.
Jesamine C. Bartlett, Richard James Radcliffe, Pete Convey, Kevin A. Hughes, Scott A.L. Hayward, 2020.
2018
Evaluation of the systemic toxicity and mutagenicity of OLIGOPIN®, procyanidolic oligomers (OPC) extracted from French Maritime Pine Bark Extract. Toxicology Reports 5: 531–541.
Segal, L., Penman, M. and Piriou, Y. 2018.
2018
Investigation of the potential non-genotoxic mode of action for 1,2-Dichloroethane (DCE)-induced mammary tumors in female rats. Toxicology Letters, Volume 295, Supplement 1, Pages S150-S151, P11-06
D.R.Boverhof, J.A.Hotchkiss, M.J.LeBaron, L.M.Segal, C.Howick, 2018.
2018
Signal management in pharmacovigilance and human risk assessment of CpG 7909, integrating embryo-fetal and post-natal developmental toxicity studies in rats and rabbits. Reproductive Toxicology, 75, pp.110-120.
Delannois, F., Planty, C., Giordano, G., Destexhe, E., Stanislaus, D., Da Silva, F.T., Stegmann, J.U., Thacker, K., Reynaud, L., Garçon, N. and Segal, L., 2018.
2017
Extended OECD 422 screening study for the evaluation of substances with suspected reproductive toxicity and/or endocrine activity. Toxicology Letters, 280, p.S163.
Segal, L., Canut, L., Myers, D., García, S., Blee, M., Butala, J. and Penman, M., 2017.
2017
Intramuscularly administered herpes zoster subunit vaccine has no effects on fertility, pre-and post-natal development in Sprague-Dawley rats. Reproductive Toxicology, 69, pp.297-307.
Segal, L., Thacker, K., Fochesato, M., Giordano, G., Garçon, N. and Destexhe, E., 2017.
2016
Strategies to address REACH Annex X requirements for developmental toxicity testing in a second mammalian species. Society of Toxicology Annual Meeting 2016, Late‐Breaking Abstracts Poster abstract ID: 3614 Poster Board: P306
Penman, M., Riley, A.,Candido, A.,Wood, E., Myers, D. and Segal, L. 2016.
2015
A mechanistic approach to read-across & minimising animal testing. Speciality Chemicals Magazine, pp. 46-47.
Penman, M. and Piper, M. 2015.
2015
Olefins and chemical regulation in Europe: REACH. Chemico-biological interactions, 241, pp.59-65.
Penman, M., Banton, M., Erler, S., Moore, N. and Semmler, K., 2015.
2013
A systematic approach for evaluating and scoring human data. Regulatory Toxicology and Pharmacology, 66(2), pp.241-247.
Money, C.D., Tomenson, J.A., Penman, M.G., Boogaard, P.J. and Lewis, R.J., 2013.
2013
The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
Bergkamp, L. and Penman, M. 2013.Introduction. In: Bergkamp, L. ed., 2013.
2013
The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
Bergkamp, L. and Penman, M. 2013. Conclusion. In: Bergkamp, L. ed., 2013.
2013
The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
Grosso, A., Crane, M. and Penman, M. 2013. REACH and strategic decision making. In: Bergkamp, L. ed., 2013.
2013
The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
Hansen, B. and Penman, M. 2013. Is REACH achieving its objectives?. In: Bergkamp, L. ed., 2013.
2013
The European Union REACH regulation for chemicals: Law and practice. OUP Oxford.
Penman, M. and Richards, M. 2013. REACH Consortia. In: Bergkamp, L. ed., 2013.
2007
The ECETOC approach to targeted risk assessment; lessons and experiences relevant to REACH. Journal of Exposure Science and Environmental Epidemiology, 17(S1), p.S67.
Money, C.D., Jacobi, S., Penman, M.G., Rodriguez, C., De Rooij, C. and Veenstra, G., 2007.