Endocrine Disruption

Endocrine disruptor assessment and expert support for regulatory compliance

Mechanistic, regulator-aligned ED assessments designed to deliver defensible conclusions and strategic risk management.

What We Do

Comprehensive solutions for understanding and managing ED liability.

Following the inclusion of endocrine disruptor (ED) hazard classes in the CLP (2023), registrants and downstream users are legally required to assess the ED potential of their substances. We help navigate this complex regulatory landscape by reviewing existing datasets to identify ED triggers relevant to both human health and the environment.

Where data gaps are identified, we design targeted testing strategies to generate the necessary evidence, ensuring compliance while minimising unnecessary studies. Our team conducts formal ED assessments in accordance with current regulatory guidance, providing clear, robust conclusions.

For cases where rodent studies indicate potential ED concerns, we design and execute mechanistic investigations to determine whether these effects are real and, if so, relevant to humans. This approach ensures scientifically sound and regulatory-compliant outcomes for your substances.

The Challenge

Endocrine disruptor liability: a market access barrier.

Estimating endocrine disruptor (ED) liability can be challenging, as it depends on both the volume and commercial significance of your registered substance. This is compounded by a widespread lack of ED-specific data for industrial chemicals.

With Category 1 ED classification highly likely to trigger usage restrictions, and ED assessment now a mandatory legal requirement, companies face increasing regulatory and commercial pressure. Notably, over 25,000 REACH registrations currently lack any ED evaluation, highlighting the urgent need for robust, compliant assessments.

The Solution

Proactive ED assessment for compliance and market access.

Navigating endocrine disruptor (ED) regulations requires both scientific expertise and strategic foresight. Acting early allows registrants to understand their substance’s ED liability, ensure product safety, and maintain market access.

In-house ED expertise to support comprehensive assessments

Dedicated endocrine disruption specialists deliver comprehensive, scientifically robust assessments tailored to regulatory requirements through our Active Steward™ platform.

Human relevance evaluation

We assess whether observed endocrine effects are relevant to humans, supporting sound, evidence-based regulatory conclusions.

Protection of market access

Scientifically justified assessments can help limit unnecessary classification while ensuring continued compliance and product safety.

Proactive regulatory and strategic support

We help registrants anticipate legal requirements and make informed, strategic decisions on long-term substance management.

The Result

Achieve regulatory compliance, safeguard product safety, and maintain market access.

Clients benefit from robust, fully interpreted toxicological data that supports successful registration, regulatory confidence, and faster market access.

Why Choose Us?

Your trusted partner for ED assessments.

Integrated regulatory insight, scientific depth, and strategic judgement for endocrine disruptor compliance.

Regulatory Expertise

In-depth understanding of evolving ED requirements under CLP and REACH, providing confident navigation of current and emerging regulatory expectations.

Scientifically Robust Assessments

Evidence-based ED evaluations, including mechanistic analysis where needed, to determine human relevance and support defensible regulatory conclusions.

Strategic Risk & Data Management

Clear, actionable insights that minimise unnecessary testing, avoid unwarranted classification, protect market access and support long-term substance management.

Our ED Experts

Specialist expertise in endocrine disruptor assessment and regulatory strategy.

Our in-house team provides the expertise to evaluate, interpret, and manage ED hazards effectively. With a deep understanding of ED and regulatory requirements, they design targeted testing strategies, carry out mechanistic investigations, and deliver clear, evidence-based assessments.

Audric Mathuren

Exposure Scientist

Stefano Moretta

Environmental Scientist

Alexia Pelloux

Environmental Scientist

Regulatory Compliance Is Mandatory

Ensure your substances meet regulatory requirements, safeguard product safety, and maintain market access with our proactive ED assessment and support.

Understand your ED risk now